DRHC Dubai Dermatology Clinic

Systemic Treatment of Psoriasis - Skin Specialist in Dubai

Systemic treatments are often prescribed for individuals with moderate to severe psoriasis that affects a large area of the body or does not respond to traditional topical treatments.

Systemic treatments for psoriasis come with potential side effects and risks. Regular monitoring and follow-up are crucial to managing the condition effectively and ensuring the safety of the chosen treatment.

Here are some common systemic treatment options for psoriasis:


Methotrexate is medication that works by suppressing the immune system. It can help reduce inflammation, slow down the rapid growth of skin cells, and alleviate symptoms of psoriasis. Regular blood tests are required to monitor liver function and potential side effects.

Methotrexate is given once weekly single dose either orally or by injections, together with folic acid supplementations.

The improvement is noted usually within 3-6 weeks, and may take up to 6 months for complete cure.

Systemic retinoids (Acitretin):

Is vitamin A derivatives’, is an oral retinoid that helps normalize the excessive growth of skin cells. It can be particularly useful for psoriasis affecting the palms, soles, and nails.

It has Anti proliferative and Anti-inflammatory effect that reduce the psoriasis symptoms, the result appears after 2-4 months.

Is usually given with combination of other treatment in severe psoriasis

However, acitretin is not recommended for women of childbearing age, as it can cause birth defects.


Is an immunosuppressive that inhibit the activity of psoriatic immune cells and reduces the immune system's activity, it provides relief within few weeks and total cure within 3-4 months.

It can be effective in treating severe psoriasis but is usually used for short durations due to potential side effects, including kidney problems and high blood pressure.

Other systemic therapy

  • Azathioprine
  • Mycophenolate mofetil
  • Tacrolimus

At Dr Rami Hamed Center, we understand the challenges that psoriasis presents, and our team of experts is dedicated to providing you with the most advanced and effective topical treatments available. Contact us today to schedule a consultation and take the first step toward managing your psoriasis with confidence and comfort.

Dermatology Clinic Dubai at Dr. Rami Hamed Center provides one of the top dermatologists in Dubai for the treatment of various skin-related diseases. If you are looking for a good skin doctor in Dubai call +97142798200. Skin Care & Treatment Clinics in DubaiDRHC also offers PRP treatmentFillers, etc. DRHC provides technological treatment for anti-aging and rejuvenation procedures by the best Dermatologist in Dubai.