Hashimoto Disease (Lymphocytic Thyroiditis)
It is the most common inflammatory disorder of the thyroid and the leading cause of hypothyroidism.
Hashimoto's thyroiditis is an auto immune process with specificity for thyroid antigens against thyroid cells and receptors.
Hypothyroidism results not only from the destruction of thyrocytes and also from block TSH-R.
It is common in women (male - female ratio 1:10 ) between the ages of 30 and 50 years old. The most common presentation is that of a minimally or moderately enlarged firm granular gland discovered on routine physical examination or the awareness of a painless anterior neck mass. 20% of patients present with hypothyroidism. 5% present with hyperthyroidism.
Thyroid hormone replacement with a goal of maintaining normal TSH levels.
It may occasionally be indicated for suspicion of malignancy or for goiters causing compressive symptoms or cosmetic deformity.